Kisspeptins: New Local Modulators of Testis Activity
نویسنده
چکیده
Spermatogenesis, the process that leads the production of male gametes, consists in the progression of mitotic spermatogonia toward meiosis and spermiogenesis in order to produce functional spermatozoa. This complex process requires a deep network among a wide set of endocrine, paracrine and autocrine factors exerting their activity at different levels along the hypothalamus-pituitary-gonad (HPG) axis. The upstream activity of hypothalamic Gonadotropin Releasing Hormone (GnRH) is followed by the secretion of pituitary gonadotropins [Follicle stimulating hormone (FSH) and Luteinizing Hormone (LH)] which in turn promote testosterone biosynthesis from the testis. Such an endocrine route is locally integrated by several local modulators that ensure the progression of the spermatogenesis through the fine communications among germ cells and somatic cells interstitial Leydig cells and nurse Sertoli cells in the germinal epithelium-.
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